Concepts of mutual interdependence, process, creative advance, and God occupy key areas in the philosophy of Alfred North Whitehead. Process metaphysics lays emphasis on a naturalism of rigorous rational and empirical methodology with far-reaching implications. Process thinkers have compared Whiteheadian thought to Buddhism, Christianity, and many other religions. However, African religious beliefs have yet to be considered in this area of study. Based on the gap in the literature, this article attempts to reconcile such seemingly different spheres. First, I offer an account of Whitehead's process metaphysics regarding the concepts mentioned above. Second, I argue that nonconventional sources of African philosophy offer conceptual understandings of philosophies of African groups and their place in the metaphysical debate. Third, I discuss these key areas of process thought in Anlo traditional pragmatic philosophy. I illustrate their like-mindedness with process metaphysics through language, religious rites, and historical accounts. I conclude that, although process philosophy overlaps in prominent areas with Anlo belief systems, questions regarding the causal nature of God distinguish the Anlo conception of divinity from that of process philosophy.