Individuals living with human immunodeficiency virus (HIV) are faced with numerous issues, including access to medications and food, as well as the struggle to pay for day-to-day expenses, such as utilities. This cross-sectional study examines the levels of food security and depression among eighty-two individuals living with HIV/AIDS in rural Appalachia. More than half of the participants (n = forty-five, 54.9 percent) were living in food insecure households. Participants were categorized as depressed as follows: minimally depressed (n = twenty-four, 29.3 percent), mildly (n = twenty-seven, 32.9 percent), moderately (n = ten, 12.2 percent), moderately severely (n = eight, 9.8 percent), or severely (n = ten, 12.2 percent). Food insecurity was significantly correlated with depression (taub = 0.406, p < 0.001). This study supports that individuals living with HIV/AIDS in this sample have decreased access to resources needed for food and are prone to depression.

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