Murray and Olive Titus were American Methodist missionaries who served in India in the first half of the twentieth century. They were outstanding academically, and educational work was central to their missionary endeavours. However, the range of their work expanded greatly during their time in India, tumultuous decades that included world war and independence. This article examines their various areas of ministry, including Murray’s personal and scholarly engagement with Islam, and Olive’s concerns for social and economic development. They both learned to teach and preach in the vernacular, and their interest in and respect for India’s faiths and traditions were appreciated.