An assessment framework was developed and implemented for UCLA’s science general education (GE) program that combined overall program goals, individual course improvement, and faculty engagement. Specifically, the framework targeted (a) developing institutional goals for GE courses, (b) ensuring alignment of individual course learning outcomes with institutional goals, (c) exploring the student experience during GE courses, and (d) engaging faculty to understand the classroom experience. Using the methods detailed, information was gathered regarding student learning experiences, scientific skill/literacy level, and attitudes toward science after completing the GE course. Furthermore, this process also facilitated faculty involvement in the assessment and an improved awareness about course pedagogy. This framework can be applied to assess other general education programs (diversity, writing, etc.) or even individual departmental science programs.